The differences between the two profiles are listed in the latest AOIP recommendation document AES67 Requirements and Recommendations
See page 13 section 3.3.3.
At EHX V11.1 by Default Clear-Com uses the AES67 Media Profile.
At EHX V12 you can select to use the AES67 Media Profile or the ST2110 ( == SMPTE 2059-2) Profile.