The differences between the two profiles are listed in the latest AOIP recommendation document  AES67 Requirements and Recommendations

See page 13 section 3.3.3.  

At EHX V11.1 by Default Clear-Com uses the AES67 Media Profile. 

  At EHX V12 you can select to use the AES67 Media Profile or the ST2110 ( == SMPTE 2059-2) Profile.